Digestive Enzymes

Also known as: amylase, lipase, protease, lactase, bromelain, papain

Grade B — Moderate Evidenceenzymegut

Recommended Dosage

1–2 capsules

Always with food — enzymes must contact food substrate. Take at start of meal.

Enzyme supplementation for digestive support. Standard of care for pancreatic insufficiency. Lactase highly effective for lactose intolerance.

🦠Gut Health
Last reviewed: 2026-03-09

Evidence Rating: Grade B — Moderate Evidence

Some RCTs with positive results, or strong observational evidence. More research may refine our understanding.

Interaction Warnings

WarfarinModerate

Bromelain may enhance anticoagulant effect; monitor INR

Acarbose (diabetes drug)Moderate

Amylase enzymes reduce acarbose efficacy; avoid combining

⚠️ Important Notes

  • Standard of care for pancreatic insufficiency
  • Not a substitute for addressing root cause of maldigestion
  • Plant enzymes available for vegans

Clinical Evidence (2 studies)

Pancreatic exocrine insufficiency and enzyme replacement

Domínguez-Muñoz JE (2011) — Gut

Clinical review of dosing and efficacy for enzyme replacement

View on PubMed

Lactase enzyme for lactose intolerance

Suarez FL et al. (1999) — Am J Clin Nutr

Effectively reduces lactose maldigestion in lactose-intolerant adults; RCT

View on PubMed

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⚕️ Important Disclaimer

This information is for educational purposes only. It is not medical advice. Always consult a healthcare provider before starting any supplement regimen, especially if you take medications or have health conditions.

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