Saffron

Also known as: Crocus sativus, kesar, zafran, Safr'Inside

Grade A — Strong Evidenceherbmood

Recommended Dosage

30–30 mg

With meals, twice daily (15mg AM + 15mg PM). Full effects at 6-8 weeks.

Potent natural antidepressant with multiple RCTs showing comparable efficacy to fluoxetine at just 30mg/day. Also supports eye health.

😊Mood🧠Cognitive Performance
Last reviewed: 2026-03-09

Evidence Rating: Grade A — Strong Evidence

Multiple high-quality RCTs, systematic reviews, or meta-analyses with consistent findings.

Interaction Warnings

SSRIs/antidepressantsModerate

Additive serotonergic effect; monitor

AnticoagulantsLow

Weak antiplatelet; monitor warfarin

AntihypertensivesLow

Mild blood pressure lowering; monitor

⚠️ Important Notes

  • High doses (>5g) toxic — uterine stimulant
  • Avoid supplemental doses in pregnancy
  • Cost-effective as supplement, not as culinary spice

Clinical Evidence (3 studies)

Saffron vs placebo for depression

Akhondzadeh S et al. (2005) — Phytother Res

Significant antidepressant effect at 30mg/day; RCT

View on PubMed

Saffron vs fluoxetine: comparable efficacy

Noorbala AA et al. (2005) — J Ethnopharmacol

Comparable efficacy to fluoxetine at 30mg/day; double-blind pilot RCT

View on PubMed

Meta-analysis: saffron for depression

Shafiee M et al. (2020) — J Integr Med

Significantly superior to placebo for depression

View on PubMed

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⚕️ Important Disclaimer

This information is for educational purposes only. It is not medical advice. Always consult a healthcare provider before starting any supplement regimen, especially if you take medications or have health conditions.

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