Beta-Glucan

Also known as: β-1,3/1,6-D-glucan, oat beta-glucan, yeast beta-glucan, Wellmune

Grade B — Moderate Evidencepolysaccharideimmuneheart

Recommended Dosage

250–500 mg

Immune (yeast form): empty stomach morning. Cholesterol (oat form): with meals.

Dual-purpose supplement: yeast-derived for immune support (250mg), oat-derived for cholesterol (3g). Both well-supported by RCTs.

🛡️Immunity❤️Heart Health
Last reviewed: 2026-03-09

Evidence Rating: Grade B — Moderate Evidence

Some RCTs with positive results, or strong observational evidence. More research may refine our understanding.

Interaction Warnings

ImmunosuppressantsModerate

Stimulates innate immunity; may counteract immunosuppressive drugs

⚠️ Important Notes

  • Yeast-derived for immune; oat-derived for cholesterol — different structures
  • Yeast allergy: caution with yeast-derived forms
  • FDA-approved health claim for oat beta-glucan and cholesterol

Clinical Evidence (2 studies)

Yeast beta-glucan reduced URTI in marathon runners

Talbott SM, Talbott JA (2012) — J Am Coll Nutr

250mg/day significantly reduced URTI incidence and severity; RCT

View on PubMed

Oat beta-glucan meta-analysis for cholesterol

Ho HV et al. (2016) — Eur J Clin Nutr

3g/day lowers LDL cholesterol ~0.25 mmol/L; 28 RCTs

View on PubMed

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⚕️ Important Disclaimer

This information is for educational purposes only. It is not medical advice. Always consult a healthcare provider before starting any supplement regimen, especially if you take medications or have health conditions.

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