Garlic / Allicin

Also known as: Allium sativum, aged garlic extract, AGE, Kyolic garlic, allicin

Grade A — Strong Evidenceherbheartantimicrobial

Recommended Dosage

600–1200 mg aged garlic extract

With meals to minimize GI upset and odor. Consistent daily use (8+ weeks).

Strong RCT evidence for blood pressure reduction (~8-9/5-6 mmHg) and cold prevention (64% reduction). Aged extract preferred for CV.

❤️Heart Health🛡️Immunity
Last reviewed: 2026-03-09

Evidence Rating: Grade A — Strong Evidence

Multiple high-quality RCTs, systematic reviews, or meta-analyses with consistent findings.

Interaction Warnings

Warfarin / anticoagulantsHigh Risk

Additive antiplatelet effect; monitor INR; stop 7-10 days before surgery

Saquinavir (HIV medication)High Risk

Significantly reduces saquinavir levels; CONTRAINDICATED

NSAIDsModerate

Additive antiplatelet at high doses

⚠️ Important Notes

  • Aged garlic extract (Kyolic) is odorless and best studied for CV
  • Fresh: crush and wait 10 min for allicin formation
  • Stop before surgery

Clinical Evidence (3 studies)

Aged garlic extract for blood pressure

Ried K et al. (2016) — Maturitas

Meta-analysis of 12 RCTs: -8.7 systolic, -6.1 diastolic mmHg

View on PubMed

Garlic preparations and cholesterol

Reinhart KM et al. (2009) — Ann Pharmacother

Meta-analysis of 29 RCTs: modest but significant LDL reduction

View on PubMed

Allicin garlic reduced cold incidence 64%

Josling P (2001) — Adv Ther

Allicin-releasing capsules reduced cold incidence 64% over 12 weeks; RCT

View on PubMed

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⚕️ Important Disclaimer

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