Magnesium L-Threonate

Also known as: magtein

Grade B — Moderate Evidencemineralcognitive
1000–2000 mgEvening or split AM/PM

Magnesium L-Threonate (branded as Magtein) is the only form of magnesium demonstrated to significantly increase magnesium levels in the brain by crossing the blood-brain barrier. Developed at MIT, this form has shown promise for cognitive enhancement, memory support, and potentially slowing age-related cognitive decline. While more expensive than other magnesium forms, it fills a unique niche for brain-targeted supplementation.

TL;DR: The only magnesium form shown to cross the blood-brain barrier effectively. Promising for cognitive function and brain aging.

🧠Cognitive Performance🎯Focus🌙Sleep
Last reviewed: 2026-03-10

Evidence Rating: Grade B — Moderate Evidence

Some RCTs with positive results, or strong observational evidence. More research may refine our understanding.

Forms Comparison

Magnesium L-Threonate

✓ High Absorption

Only form shown to significantly cross the blood-brain barrier. Premium priced.

cognitive functionbrain agingmemory

Magnesium Glycinate

✓ High Absorption

Chelated with glycine for high absorption and calming effect.

sleepanxietygeneral deficiency

Magnesium Citrate

~ Moderate Absorption

Good bioavailability and affordable. Mild laxative effect.

constipationgeneral supplementation

Interaction Warnings

AntibioticsModerate

Separate by 2 hours

⚠️ Important Notes

  • More expensive than other magnesium forms

Clinical Evidence (1 study)

Enhancement of learning and memory by elevating brain magnesium

Bhatt DK et al. (2010) — Neuron

MgT uniquely crosses BBB and enhances synaptic density

View on PubMed

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⚕️ Important Disclaimer

This information is for educational purposes only. It is not medical advice. Always consult a healthcare provider before starting any supplement regimen, especially if you take medications or have health conditions.

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