Alpha-GPC

Also known as: alpha-glycerophosphocholine, choline alfoscerate, α-GPC

Grade B — Moderate Evidencenootropiccholine

Recommended Dosage

300–600 mg

Morning with food. Avoid evening — may interfere with sleep.

Most bioavailable choline source for the brain. Supports acetylcholine production for memory, focus, and muscle contraction.

🧠Cognitive Performance🎯Focus💪Muscle & Recovery
Last reviewed: 2026-03-09

Evidence Rating: Grade B — Moderate Evidence

Some RCTs with positive results, or strong observational evidence. More research may refine our understanding.

Interaction Warnings

Anticholinergic medicationsModerate

Antagonistic — may reduce efficacy of diphenhydramine, scopolamine

Cholinesterase inhibitors (donepezil)Moderate

Additive cholinergic effects; monitor

⚠️ Important Notes

  • Acetylcholine precursor — may cause headaches if over-supplemented
  • Hygroscopic — store in sealed container

Clinical Evidence (3 studies)

Alpha-GPC improved cognitive function in Alzheimer's

De Jesus Moreno Moreno M (2003) — Clin Ther

Improved cognitive function and ADAS-cog score in Alzheimer's; multicenter RCT

View on PubMed

Meta-analysis: α-GPC improved cognition in neurological conditions

Rano C et al. (2023) — J Clin Med

Systematic review confirming cognitive benefits

View on PubMed

Alpha-GPC augmented growth hormone and bench press force

Ziegenfuss T et al. (2008) — J Int Soc Sports Nutr

Increased peak bench press force output

View on PubMed

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CDP-Choline (Citicoline)

Grade B — Moderate Evidence

Bioavailable choline source that also elevates dopamine and acetylcholine. Cognizin form best studied for attention and working memory.

L-Theanine

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Amino acid from green tea. Promotes calm focus (alpha brain waves) without drowsiness. Excellent safety profile.

Lion's Mane

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Medicinal mushroom that stimulates NGF. Multiple RCTs show benefits for mild cognitive impairment and mood.

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⚕️ Important Disclaimer

This information is for educational purposes only. It is not medical advice. Always consult a healthcare provider before starting any supplement regimen, especially if you take medications or have health conditions.

Evidence Stack does not sell supplements and has no affiliate relationships with supplement manufacturers.