PQQ (Pyrroloquinoline Quinone)

Also known as: PQQ, BioPQQ, methoxatin

Grade C — Preliminaryantioxidantmitochondrial

Recommended Dosage

10–20 mg

Morning with food. Often stacked with CoQ10.

Stimulates mitochondrial biogenesis (creation of new mitochondria). Best paired with CoQ10. Still early research.

🧠Cognitive Performance⚡Energy🧬Longevity
Last reviewed: 2026-03-09

Evidence Rating: Grade C — Preliminary

Limited human trials, mostly animal or in-vitro data. Promising but not yet proven in robust human studies.

⚠️ Important Notes

  • Synergistic with CoQ10
  • Limited but promising human data
  • Expensive
  • Use BioPQQ standardized form

Clinical Evidence (2 studies)

PQQ improved cognitive function in healthy elderly

Shiojima Y et al. (2013) — Food Funct

PQQ 20mg improved cognitive function in healthy elderly; randomized study

View on PubMed

PQQ review: mitochondrial biogenesis and neuroprotection

Rucker R et al. (2009) — J Nutr Biochem

Comprehensive review of PQQ mechanisms

View on PubMed

Related Supplements

CoQ10 (Ubiquinol)

Grade A — Strong Evidence

Critical for mitochondrial energy production. Q-SYMBIO trial showed 43% cardiovascular mortality reduction in heart failure. Depleted by statins.

Astaxanthin

Grade C — Preliminary

Extremely potent antioxidant carotenoid. Promising for skin health and exercise recovery. Still building human evidence.

Omega-3 Fish Oil

Grade A — Strong Evidence

Essential fatty acids with strong evidence for cardiovascular and mental health. EPA-dominant for mood; triglyceride form for absorption.

Creatine Monohydrate

Grade A — Strong Evidence

One of the most researched supplements in history. Strong evidence for strength, power, and emerging evidence for brain function.

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⚕️ Important Disclaimer

This information is for educational purposes only. It is not medical advice. Always consult a healthcare provider before starting any supplement regimen, especially if you take medications or have health conditions.

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