Resveratrol

Also known as: trans-resveratrol, 3,4',5-trihydroxystilbene

Grade B — Moderate Evidencepolyphenollongevity

Recommended Dosage

100–500 mg

With fat-containing meal. Morning preferred.

SIRT1 activator commonly combined with NMN/NR. Human evidence for metabolic improvement and cognitive support. Lipid-soluble — take with fat.

🧬Longevity❤️Heart Health🧠Cognitive Performance
Last reviewed: 2026-03-09

Evidence Rating: Grade B — Moderate Evidence

Some RCTs with positive results, or strong observational evidence. More research may refine our understanding.

Interaction Warnings

WarfarinModerate

Inhibits CYP2C9; may increase warfarin levels and bleeding risk

Statins (simvastatin, lovastatin)Moderate

CYP3A4 inhibition may increase statin levels

NSAIDsLow

Additive antiplatelet effects

⚠️ Important Notes

  • Use trans-resveratrol form (cis-form is inactive)
  • GI side effects at >1g/day
  • Weak phytoestrogen — caution in hormone-sensitive cancers

Clinical Evidence (3 studies)

Resveratrol extended lifespan in obese mice

Baur JA et al. (2006) — Nature

Landmark animal study: extended lifespan and improved metabolic function

View on PubMed

Resveratrol improved metabolic syndrome markers

Timmers S et al. (2011) — Cell Metab

150mg improved metabolic syndrome markers in obese men; human RCT

View on PubMed

Resveratrol improved cerebrovascular function and cognition

Kennedy DO et al. (2010) — Am J Clin Nutr

Improved cerebrovascular function and cognitive performance in older adults

View on PubMed

Related Supplements

Spermidine

Grade B — Moderate Evidence

Autophagy inducer with strong epidemiological link to reduced all-cause mortality. RCT evidence for memory improvement in elderly.

Omega-3 Fish Oil

Grade A — Strong Evidence

Essential fatty acids with strong evidence for cardiovascular and mental health. EPA-dominant for mood; triglyceride form for absorption.

Taurine

Grade B — Moderate Evidence

Conditionally essential amino acid. Landmark 2023 Science paper showed it extends healthy lifespan in multiple species.

NR (Nicotinamide Riboside)

Grade B — Moderate Evidence

NAD+ precursor with strong human RCT evidence for NAD+ elevation. Unique cardiovascular benefits: reduced arterial stiffness and blood pressure.

🧪 Get Your Personalized Stack

See how Resveratrol fits with your goals and current supplements — AI-powered, evidence-graded recommendations.

⚕️ Important Disclaimer

This information is for educational purposes only. It is not medical advice. Always consult a healthcare provider before starting any supplement regimen, especially if you take medications or have health conditions.

Evidence Stack does not sell supplements and has no affiliate relationships with supplement manufacturers.