Spermidine

Also known as: polyamine, wheat germ extract (spermidine-rich)

Grade B — Moderate Evidencepolyaminelongevity

Recommended Dosage

1–2 mg

With food. Consistent daily use.

Autophagy inducer with strong epidemiological link to reduced all-cause mortality. RCT evidence for memory improvement in elderly.

🧬Longevity🧠Cognitive Performance❤️Heart Health
Last reviewed: 2026-03-09

Evidence Rating: Grade B — Moderate Evidence

Some RCTs with positive results, or strong observational evidence. More research may refine our understanding.

⚠️ Important Notes

  • Food-equivalent doses; excellent safety
  • Wheat germ extract is most studied supplemental form
  • Also found in natto, mushrooms, aged cheese

Clinical Evidence (3 studies)

Higher dietary spermidine linked to lower all-cause mortality

Kiechl S et al. (2018) — Am J Clin Nutr

Large prospective cohort: lower mortality across spermidine intake thirds

View on PubMed

Spermidine improved memory in at-risk elderly

Wirth M et al. (2021) — Nat Aging

Supplementation improved memory in at-risk elderly; RCT

View on PubMed

Spermidine extended lifespan and reduced cardiac aging

Eisenberg T et al. (2016) — Nat Med

Extended lifespan in multiple species

View on PubMed

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⚕️ Important Disclaimer

This information is for educational purposes only. It is not medical advice. Always consult a healthcare provider before starting any supplement regimen, especially if you take medications or have health conditions.

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