Sulforaphane

Also known as: broccoli sprout extract, SFN, glucoraphanin + myrosinase, Avmacol

Grade B — Moderate Evidenceisothiocyanatedetox

Recommended Dosage

10–40 mg

Morning with food. Do not heat broccoli/sprouts (destroys myrosinase).

Powerful Nrf2 activator from cruciferous vegetables. Evidence for air pollution detoxification and H. pylori eradication.

🧬Longevity🛡️Immunity🦠Gut Health
Last reviewed: 2026-03-09

Evidence Rating: Grade B — Moderate Evidence

Some RCTs with positive results, or strong observational evidence. More research may refine our understanding.

Interaction Warnings

CYP1A2 substratesLow

May affect metabolism of certain drugs via CYP induction

WarfarinLow

Sulforaphane may affect CYP2C9; monitor

⚠️ Important Notes

  • Myrosinase enzyme needed for activation — look for products containing it
  • Fresh broccoli sprouts are the best source
  • Add mustard seeds to heated broccoli to restore myrosinase

Clinical Evidence (3 studies)

Sulforaphane clinical evidence: bioavailability and Nrf2 pathway

Fahey JW et al. (2015) — Cancer Prev Res

Review of sulforaphane: bioavailability, Nrf2 pathway activation, human trials

View on PubMed

Broccoli sprout beverage increased excretion of air pollution carcinogens

Egner PA et al. (2014) — Cancer Prev Res

Increased excretion of benzene and acrolein in Chinese trial

View on PubMed

Broccoli sprouts reduced H. pylori colonization

Yanaka A et al. (2009) — Cancer Prev Res

Reduced H. pylori colonization and gastric inflammation

View on PubMed

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⚕️ Important Disclaimer

This information is for educational purposes only. It is not medical advice. Always consult a healthcare provider before starting any supplement regimen, especially if you take medications or have health conditions.

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