Vitamin K2 (MK-7)

Also known as: menaquinone-7, vitamin K2, MK-7

Grade B — Moderate Evidencevitaminfoundational
100–200 mcgWith Vitamin D3 and fat-containing meal

Vitamin K2 (menaquinone-7) plays a crucial role in calcium metabolism by activating proteins that direct calcium to bones and teeth while keeping it out of soft tissues and arteries. It's the essential partner to Vitamin D3 — without adequate K2, the increased calcium absorption from D3 may end up in arteries rather than bones. Most people are deficient because K2 is found mainly in fermented foods like natto, hard cheeses, and certain organ meats.

TL;DR: Directs calcium to bones and teeth, away from arteries. Essential when supplementing Vitamin D3.

❤️Heart Health🧬Longevity
Last reviewed: 2026-03-10

Evidence Rating: Grade B — Moderate Evidence

Some RCTs with positive results, or strong observational evidence. More research may refine our understanding.

Interaction Warnings

WarfarinHigh Risk

Directly counteracts warfarin. INR monitoring required. Contraindicated without supervision.

⚠️ Important Notes

  • Essential partner for Vitamin D3
  • Directs calcium to bones instead of arteries
  • Very safe; no known toxicity at supplemental doses

Clinical Evidence (2 studies)

MK-7 supplementation improves arterial stiffness and bone strength

Knapen MH et al. (2013) — Osteoporos Int

Improved arterial stiffness and bone strength markers in postmenopausal women

View on PubMed

Menaquinone-7 and arterial stiffness

Knapen MH et al. (2015) — Thromb Haemost

Improved arterial stiffness and reduced age-related vascular calcification

View on PubMed

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⚕️ Important Disclaimer

This information is for educational purposes only. It is not medical advice. Always consult a healthcare provider before starting any supplement regimen, especially if you take medications or have health conditions.

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