Phosphatidylserine

Also known as: PS, phosphatidylserine

Grade B — Moderate Evidencephospholipidnootropic

Recommended Dosage

100–300 mg

With meals (fat-soluble). Divide across 2-3 meals.

Phospholipid that supports cell membrane integrity in the brain. FDA-qualified health claim for cognitive decline. Reduces cortisol.

🧠Cognitive Performance🧘Stress & Anxiety🎯Focus💪Muscle & Recovery
Last reviewed: 2026-03-09

Evidence Rating: Grade B — Moderate Evidence

Some RCTs with positive results, or strong observational evidence. More research may refine our understanding.

Interaction Warnings

Blood thinnersLow

Possible mild antiplatelet effect; monitor

Anticholinergic drugsLow

Potential antagonism

Cholinesterase inhibitorsLow

Additive cholinergic effects

⚠️ Important Notes

  • Soy-derived vs sunflower-derived available
  • Well-tolerated
  • FDA-qualified health claim for age-related cognitive decline

Clinical Evidence (2 studies)

PS improved memory and cognitive function in elderly

Vakhapova V et al. (2010) — Am J Clin Nutr

PS supplementation improved memory and cognitive function

View on PubMed

PS blunted exercise-induced cortisol

Hellhammer J et al. (2004) — Neurobiol Stress

Blunted exercise-induced cortisol and ACTH increases

View on PubMed

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Bacopa Monnieri

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Lion's Mane

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⚕️ Important Disclaimer

This information is for educational purposes only. It is not medical advice. Always consult a healthcare provider before starting any supplement regimen, especially if you take medications or have health conditions.

Evidence Stack does not sell supplements and has no affiliate relationships with supplement manufacturers.