CDP-Choline (Citicoline)

Also known as: citicoline, cytidine diphosphocholine, Cognizin, Ceraxon

Grade B — Moderate Evidencenootropiccholine

Recommended Dosage

250–500 mg

Morning with food. Stimulatory — avoid evening.

Bioavailable choline source that also elevates dopamine and acetylcholine. Cognizin form best studied for attention and working memory.

🧠Cognitive Performance🎯Focus
Last reviewed: 2026-03-09

Evidence Rating: Grade B — Moderate Evidence

Some RCTs with positive results, or strong observational evidence. More research may refine our understanding.

Interaction Warnings

Levodopa (Parkinson's)Moderate

May enhance dopaminergic effects; monitor

Alpha-GPCLow

Redundant choline source; choose one per stack

⚠️ Important Notes

  • Choose one choline source: either CDP-choline OR Alpha-GPC
  • Excellent safety profile
  • Also elevates dopamine

Clinical Evidence (2 studies)

Citicoline: comprehensive review

Secades JJ & Lorenzo JL (2006) — Methods Find Exp Clin Pharmacol

Comprehensive review of mechanism and clinical evidence for stroke and cognition

View on PubMed

Citicoline improved attention in healthy adults

McGlade E et al. (2012) — Food Nutr Sci

Cognizin 250/500mg improved attention and psychomotor speed; RCT

View on PubMed

Related Supplements

Alpha-GPC

Grade B — Moderate Evidence

Most bioavailable choline source for the brain. Supports acetylcholine production for memory, focus, and muscle contraction.

L-Theanine

Grade B — Moderate Evidence

Amino acid from green tea. Promotes calm focus (alpha brain waves) without drowsiness. Excellent safety profile.

Lion's Mane

Grade B — Moderate Evidence

Medicinal mushroom that stimulates NGF. Multiple RCTs show benefits for mild cognitive impairment and mood.

Bacopa Monnieri

Grade B — Moderate Evidence

Ayurvedic herb with strong meta-analytic evidence for memory and learning. Requires consistent use for 8-12 weeks.

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⚕️ Important Disclaimer

This information is for educational purposes only. It is not medical advice. Always consult a healthcare provider before starting any supplement regimen, especially if you take medications or have health conditions.

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