Bacopa Monnieri

Also known as: bacopa, brahmi, water hyssop, KeenMind

Grade B — Moderate Evidenceherbnootropic

Recommended Dosage

300–600 mg

With fat-containing meal (standardized to 55% bacosides). Divide if >300mg.

Ayurvedic herb with strong meta-analytic evidence for memory and learning. Requires consistent use for 8-12 weeks.

🧠Cognitive Performance🎯Focus🧘Stress & Anxiety
Last reviewed: 2026-03-09

Evidence Rating: Grade B — Moderate Evidence

Some RCTs with positive results, or strong observational evidence. More research may refine our understanding.

Interaction Warnings

Thyroid medications (Levothyroxine)Moderate

May affect T4 levels; monitor thyroid function

Cholinergic medications (donepezil)Moderate

Potential additive cholinergic effects

CYP3A4/CYP2D6 substratesLow

May inhibit these enzymes; potential drug interactions

⚠️ Important Notes

  • Takes 8-12 weeks to show full cognitive benefits
  • May cause GI upset — always take with food
  • Fat-soluble bacosides need dietary fat

Clinical Evidence (3 studies)

Meta-analysis of Bacopa monnieri on cognition

Kongkeaw C et al. (2014) — J Ethnopharmacol

Meta-analysis of 9 RCTs: improved processing speed and attention

View on PubMed

Bacopa improved memory in older adults

Morgan A & Stevens J (2010) — J Altern Complement Med

Improved memory performance; RCT n=62

View on PubMed

Bacopa improved working memory and reduced anxiety

Calabrese C et al. (2008) — J Altern Complement Med

RCT in healthy elderly: improved working memory and reduced anxiety

View on PubMed

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⚕️ Important Disclaimer

This information is for educational purposes only. It is not medical advice. Always consult a healthcare provider before starting any supplement regimen, especially if you take medications or have health conditions.

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