Rhodiola Rosea

Also known as: rhodiola, golden root, arctic root, SHR-5

Grade B — Moderate Evidenceadaptogenherb

Recommended Dosage

200–600 mg

Morning on empty stomach (standardized to 3% rosavins, 1% salidroside)

Rhodiola Rosea is an adaptogenic herb native to arctic and mountainous regions of Europe and Asia, where it has been used for centuries to combat fatigue and enhance resilience. Modern research supports its role in reducing mental and physical fatigue, particularly during prolonged stress. It appears to work by modulating stress-response pathways including cortisol, key neurotransmitters, and molecular chaperones (heat shock proteins).

TL;DR: Adaptogenic herb with strong evidence for reducing stress-related fatigue. Comparable to low-dose antidepressants for mild depression.

⚡Energy🧘Stress & Anxiety🎯Focus😊Mood
Last reviewed: 2026-03-09

Evidence Rating: Grade B — Moderate Evidence

Some RCTs with positive results, or strong observational evidence. More research may refine our understanding.

Interaction Warnings

MAOIsHigh Risk

Contraindicated — may cause serotonin syndrome

SSRIs/antidepressantsModerate

May have additive serotonergic effects

StimulantsLow

Additive stimulating effects; reduce caffeine dose

⚠️ Important Notes

  • Take early in the day to avoid sleep disruption
  • Avoid in bipolar disorder — possible mania
  • Start at lower dose

Clinical Evidence (3 studies)

Rhodiola rosea reduces stress-related fatigue

Olsson EMG et al. (2009) — Planta Med

SHR-5 RCT: reduced stress-related fatigue and cortisol response

View on PubMed

Rhodiola vs sertraline in mild-moderate depression

Mao JJ et al. (2015) — Phytomedicine

Comparable efficacy to sertraline, fewer adverse effects

View on PubMed

Rhodiola for physical and mental fatigue

Hung SK et al. (2011) — Phytomedicine

Systematic review: positive evidence for fatigue reduction

View on PubMed

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⚕️ Important Disclaimer

This information is for educational purposes only. It is not medical advice. Always consult a healthcare provider before starting any supplement regimen, especially if you take medications or have health conditions.

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