Schisandra

Also known as: Schisandra chinensis, five-flavor berry, Wu Wei Zi

Grade B — Moderate Evidenceherbadaptogen

Recommended Dosage

500–2000 mg

Morning (mild energizing effect). Consistent daily use for adaptogenic benefits.

Adaptogen with liver-protective properties and military/Olympic athlete research for stress performance. CYP3A4 interactions are significant.

🧘Stress & Anxiety⚡Energy
Last reviewed: 2026-03-09

Evidence Rating: Grade B — Moderate Evidence

Some RCTs with positive results, or strong observational evidence. More research may refine our understanding.

Interaction Warnings

CYP3A4 substrates (cyclosporine, tacrolimus)High Risk

Significant CYP3A4 and P-gp inhibition; may dramatically increase drug levels

WarfarinModerate

May affect coagulation; monitor INR

⚠️ Important Notes

  • CYP3A4 inhibition is significant — review ALL concurrent medications
  • Avoid in peptic ulcer disease
  • Avoid in pregnancy

Clinical Evidence (2 studies)

Evidence-based efficacy of adaptogens

Panossian A, Wikman G (2008) — Phytother Res

Review of 1,062 studies: schisandra effective for fatigue and stress

View on PubMed

Schisandra chinensis: systematic review

Nowak A et al. (2019) — Nutrients

Hepatoprotective, antifatigue, and adaptogenic evidence

View on PubMed

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⚕️ Important Disclaimer

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