Bergamot

Also known as: Citrus bergamia, bergamot polyphenol fraction, BPF, Bergavit

Grade B — Moderate Evidencepolyphenolheartmetabolic

Recommended Dosage

500–1000 mg BPF

With meals. Consistent daily use (4-12 weeks). Morning preferred.

Impressive lipid-modifying polyphenol: 30% LDL reduction in RCTs. Natural HMG-CoA reductase inhibitor (statin-like mechanism).

❤️Heart Health
Last reviewed: 2026-03-09

Evidence Rating: Grade B — Moderate Evidence

Some RCTs with positive results, or strong observational evidence. More research may refine our understanding.

Interaction Warnings

WarfarinModerate

Furanocoumarins may inhibit CYP3A4; monitor INR

Calcium channel blockersModerate

CYP3A4 inhibition may increase drug levels

StatinsLow

Additive LDL-lowering; safe combination

⚠️ Important Notes

  • Standardized BPF extract is different from essential oil
  • CYP3A4 inhibition: review concurrent medications
  • Citrus allergy: possible cross-reactivity

Clinical Evidence (2 studies)

BPF for dyslipidemia

Mollace V et al. (2011) — Fitoterapia

1,000mg/day: 30% LDL reduction, 29% TG reduction, 40% HDL increase; RCT

View on PubMed

Bergamot polyphenols for dyslipidemia: systematic review

Toth PP et al. (2016) — Front Pharmacol

Consistent improvement across lipid parameters

View on PubMed

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⚕️ Important Disclaimer

This information is for educational purposes only. It is not medical advice. Always consult a healthcare provider before starting any supplement regimen, especially if you take medications or have health conditions.

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