Fisetin

Also known as: 3,3',4',7-tetrahydroxyflavone

Grade C — Preliminaryflavonoidlongevity

Recommended Dosage

100–500 mg

With fatty meal. For senolytic use: 500-1500mg for 2 consecutive days/month.

Most potent natural senolytic compound tested. Intermittent "hit-and-run" dosing protocol (2 days/month) for clearing senescent cells.

🧬Longevity🧠Cognitive Performance
Last reviewed: 2026-03-09

Evidence Rating: Grade C — Preliminary

Limited human trials, mostly animal or in-vitro data. Promising but not yet proven in robust human studies.

Interaction Warnings

WarfarinModerate

CYP2C9 effects; monitor INR

ImmunosuppressantsLow

Potential interaction; caution

⚠️ Important Notes

  • Intermittent dosing preferred for senolytic use
  • Low bioavailability (10-20%) — take with fat or use phytosome/liposomal
  • Human data still limited

Clinical Evidence (3 studies)

Fisetin most potent senolytic among 10 flavonoids

Yousefzadeh MJ et al. (2018) — EBioMedicine

Most potent senolytic tested; extends health/lifespan in mice

View on PubMed

Fisetin reduced biological aging markers in humans

Lee SJ et al. (2024) — Aging

Pilot RCT using TruAge methylation clock showed reduced aging markers

View on PubMed

Fisetin as senolytic targeting senescent adipocytes

Zhu Y et al. (2017) — Aging (Albany)

Effective against senescent adipocyte precursors

View on PubMed

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⚕️ Important Disclaimer

This information is for educational purposes only. It is not medical advice. Always consult a healthcare provider before starting any supplement regimen, especially if you take medications or have health conditions.

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