Nattokinase

Also known as: nattokinase, subtilisin NAT, NSK-SD, natto-derived protease

Grade B — Moderate Evidenceenzymeheartcirculation

Recommended Dosage

2000–4000 FU (fibrinolytic units)

Empty stomach for maximum fibrinolytic activity. Morning or evening.

Direct fibrinolytic enzyme from natto. Reduces blood pressure and DVT risk. Use with extreme caution regarding bleeding.

❤️Heart Health
Last reviewed: 2026-03-09

Evidence Rating: Grade B — Moderate Evidence

Some RCTs with positive results, or strong observational evidence. More research may refine our understanding.

Interaction Warnings

Warfarin / anticoagulantsHigh Risk

SIGNIFICANT — direct fibrinolytic; serious bleeding risk; avoid without physician oversight

Thrombolytics (tPA)High Risk

Additive; avoid combination

Aspirin / NSAIDsModerate

Additive antiplatelet; monitor

⚠️ Important Notes

  • ⚠️ BLEEDING RISK — direct fibrinolytic enzyme
  • CONTRAINDICATED with anticoagulants without supervision
  • Stop 2 weeks before surgery
  • CONTRAINDICATED in active bleeding or hemorrhagic stroke

Clinical Evidence (2 studies)

Nattokinase reduced blood pressure

Kim JY et al. (2008) — Nutrition

Significantly reduced BP and improved lipid markers in hypertensive subjects; RCT

View on PubMed

Nattokinase reduced venous thrombus in air travel

Cesarone MR et al. (2003) — Angiology

Reduced venous thrombus formation in long-haul travel vs placebo; RCT

View on PubMed

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⚕️ Important Disclaimer

This information is for educational purposes only. It is not medical advice. Always consult a healthcare provider before starting any supplement regimen, especially if you take medications or have health conditions.

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